A postdoctoral position of up to 3 years is available in the “Cancer Systems Pharmacology” team (Ballesta Lab) within the "Bioinformatics and Computational Systems Biology of Cancer" Unit (U900 INSERM, Mines ParisTech, Institut Curie) at Institut Curie.

The hosting structure
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Research Center is to develop fundamental research and use the produced knowledge to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory
The "Bioinformatics and Computational Systems Biology of Cancer" research unit is a very active and growing interdisciplinary department gathering bioinformaticians, biologists, physicians, mathematicians, statisticians, physicists, and computer scientists. This postdoctoral project will be hosted in the “Cancer Systems Pharmacology” team which designs mathematical and statistical approaches for optimizing and personalizing anticancer treatments integrating multi-type preclinical and clinical data. The project is a collaboration with the “Statistical Methods for Precision Medicine” team (Latouche Lab) of the unit, the Cancer chronotherapy Paris-Saclay research unit (Hôpital Paul Brousse, Villejuif), and also involves several additional teams of clinicians.

The project
The postdoctorate candidate will focus on investigating the impact of the administration timing over the 24h span of cancer immunotherapy on treatment outcomes in patients. He/She will work in the framework of a collaborative project funded by INSERM through the “Mathématiques et Informatique contre le Cancer” call (MIC, 2024-2028) that aims to enhance the efficacy of Immune Checkpoint Inhibitors (ICI) through personalized administration timing. The circadian timing system has significant influence on the immune system1 and recent preclinical and retrospective cohort studies, including one of our group2, have highlighted an association between ICI timing of administration and treatment outcomes.

The candidate will perform analysis of cohorts of patients with cancers treated with ICI in order to decipher optimal ICI timing in terms of survival, antitumor response and toxicities, accounting for the patient characteristics (e.g. sex, age, performance status, …). In addition, he/she will develop novel statistical methods for analyzing the association of drug timing with patient survival and evaluate them on both synthetic and real-world data3,4. The candidate will further investigate the optimal design of prospective clinical trials addressing the relevance of personalized administration timing regarding patient outcomes. In connection with applied mathematicians of the team, he/she may further investigate the molecular determinants of such timing dependencies using mechanistic models based on ordinary differential equations.

Key responsibilities
o Conduct original research in the area of chrono-immunotherapy
o Develop and implement biostatistics methods using synthetic or real-world clinical data
o Interact with biologists and clinicians
o Publish scientific articles at international peer-review journals
o Present results internally and at international conferences
Skills/qualifications
o PhD degree in the area of biostatistics, or applied mathematics
o Significant computational/programming skills (e.g. R, MatLab, Python)
o Experience in working with survival analysis and clinical data.
o Strong interest in biological sciences and clinical research
o Strong communication and writing skills
Contract Information
The position is available immediately and opened until filled. The salary will be set according to the Institut Curie salary grids which include a bonus for bioinformaticians. Benefits include collective catering, reimbursement of transportation fees up to 70%, and supplementary health insurance. Institut Curie also offers numerous opportunities for training in both scientific and soft skills. The location of the position is on the site of Saint-Cloud (92) of Institut Curie.

Selection process
For initial consideration and more details about the scientific areas of research, send an e-mail including your CV, a brief statement of interest and contact information for two academic references to annabelle.ballesta@inserm.fr.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.

References
1. A Lévi, F., Okyar, A., Hadadi, E., F Innominato, P. & Ballesta, A. Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy. Annu Rev Pharmacol Toxicol (2023) doi:10.1146/annurev-pharmtox-051920-095416.
2. Catozzi, S. et al. Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study. European Journal of Cancer 199, 113571 (2024).
3. Efird, J. T. Sinusoidal Cox Regression—A Rare Cancer Example. Cancer Inform 9, CIN.S6202 (2010).
4. Ramanathan, K. et al. Assessing Seasonality Variation with Harmonic Regression: Accommodations for Sharp Peaks. IJERPH 17, 1318 (2020).

The MTB group is organinizng the upcoming Conference on Models in Population Dynamics, Ecology, and Evolution (MPDEE’25). The Conference will take place at BCAM, Bilbao, from May 5-9, 2025. With a special focus on the interplay between ecology and evolution over time and space, particularly in the context of climate change, our Confirmed Keynote Speakers are:
Maíra Aguiar (BCAM, Bilbao, Spain)
Christina Cobbold (University of Glasgow, UK)
Sigrunn Eliassen (University of Bergen, Norway)
William F. Fagan (University of Maryland, USA)
Ulrike Feudel (Universitat Oldenburg, Germany)
Vincent A.A. Jansen (Royal Holloway University London, UK)
Piero Manfredi (University of Pisa, Italy)
Andrew Morozov (University of Leicester, UK)
Ricard Sole (Universitat Pompeu Fabra, Spain, and Santa Fe Institute, USA)
Honorary Speaker - Sergei Petrovskii (University of Leicester, UK)

Registration is open and the deadline for submitting your contribution is on December 15. Please visit the conference website for more information regarding registration, abstract submission, and program details.
Website: https://www.bcamath.org/events/mpdee25/en/

Join us for this exciting event to explore the intersection of mathematics and real-world challenges! We are looking forward to seeing you in Bilbao!

We invite you to the “Cell Plasticity in Cancer Evolution” workshop (May 19–22, 2025)! Connect with international experts sharing insights on cell plasticity in cancer and the latest in research and therapies.

Invited speakers:
Peter Friedl (Nijmegen)
Gaetano Gargiulo (Berlin)
Sara Hamis (Uppsala)
Mohit Kumar Jolly (Bangalore)
Purificacion Muñoz Moruno (Barcelona)
Susanne Sebens (Kiel)
Heike Siebert (Kiel)
Fabian Spill (Birmingham)

Registration url: https://workshops.evolbio.mpg.de/event/123/

BioInference aims to bring together researchers from across statistics and mathematical modelling who work with biological systems, to foster discussions and prompt collaborations between the two communities across all career stages.

After the previous three editions hosted in the UK, the BioInference 2025 conference (https://bioinference.github.io/2025) is now going abroad to Italy.

This year’s BioInference conference will take place in Bardonecchia, a town in the Alps near Turin on the 28-30 May 2025. Differently from previous editions, this year's conference is going to be a residential 3-days event that will include more talks and networking opportunities compared to previous years. A hike activity will take place on the second day!

The three-day conference will combine contributed talks and poster sessions. We now invite abstracts for oral/poster presentations on work on mathematical modelling and/or statistical methods (either development or application) for (widely defined/interpreted) biological problems. All presentations will be in-person with no-parallel sessions.

Please submit your abstract at

https://docs.google.com/forms/d/e/1FAIpQLSdxF-b-Q_TY0o0F8T_fRmgY6_SAC72w71O6Z-ITTh0ZKMXmYg/viewform

by the 31st of January 2025.

CONFIRMED INVITED SPEAKERS are Jennifer Asimit (University of Cambridge MRC Biostatistics Unit), Diego di Bernardo (Telethon Institute of Genetics and Medicine), Zhana Kuncheva (Bioxcelerate AI), Antonietta Mira (Università della Svizzera italiana (USI), Lugano), Davide Risso (Università di Padova) Jonasz Słomka (ETH Zurich), Ben Swallow (University of St Andrew's)

The registration fee (covering three lunches, all coffee breaks and one dinner) is expected to be around 185€ .

More information about the conference, talks and posters from previous years, as well as this year’s host town, Bardonecchia, can be found at https://bioinference.github.io/2025/

Kind regards,

Massimiliano on the behalf of the 2025 BioInference Organisers

We are excited to invite you to the upcoming symposium, "Rhythms, Networks, and Slow-Fast Analysis in Neural and Endocrine Systems," hosted by the Centre for Applied Mathematics in Bioscience and Medicine (CAMBAM). The event will be held at McGill University, Montreal, Canada, between June 2–6, 2025.

This symposium is co-sponsored by CAMBAM, Centre de Recherches Mathématiques, and the Department of Physiology - McGill. For more information, please visit: https://www.crmath.ca/en/activities/#/type/activity/id/4024

The full program is now available, and we are pleased to announce that poster registration is also open. A maximum of 20 posters will be accepted, so we encourage you to register soon to secure your spot. Poster submission should be made at the event page: https://www.crmath.ca/en/activities/#/type/activity/id/4024

This annual international conference is hosted in 2025 the Institute of Mathematics and Informatics and the Institute of Mechanics at the Bulgarian Academy of Sciences in Sofia.

Biomath 2025 is devoted to recent research in life sciences based on applications of mathematics as well as mathematics applied to or motivated by biological studies. It is a multidisciplinary meeting forum for researchers who develop and apply mathematical and computational tools to the study of phenomena in the broad fields of biology, ecology, medicine, biophysics, biochemistry, pharmacokinetics, chemoinformatics, biotechnology, bioengineering, environmental science, etc.

Furthermore, Biomath 2025 includes a Special Topic session on Mathematical Models of the Immune system in Human Disease.

Conference website: www.biomath.bg/2025

The University of Bristol Medical School offer intensive online short courses designed for researchers and healthcare practitioners. We are delighted to confirm that bookings for our popular Essentials of Infectious Disease Modelling and Economic Evaluation short course will open at midday on 8 October 2024.

Mathematical modelling is an important tool that can be used to understand the dynamics of infectious diseases. Academics working within Bristol Medical School, including those who tutor on the course, are involved in international research on human and zoonotic infectious diseases to help understand epidemics and predict the future burden of diseases, as well as the impact of different control measures to inform policy.

Find out more: https://www.bristol.ac.uk/medical-school/study/short-courses/courses/infectious-disease-modelling-economic-evaluation/